| http://purl.uniprot.org/citations/26524492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26524492 | http://www.w3.org/2000/01/rdf-schema#comment | "At the eukaryotic DNA replication fork, it is widely believed that the Cdc45-Mcm2-7-GINS (CMG) helicase is positioned in front to unwind DNA and that DNA polymerases trail behind the helicase. Here we used single-particle EM to directly image a Saccharomyces cerevisiae replisome. Contrary to expectations, the leading strand Pol ɛ is positioned ahead of CMG helicase, whereas Ctf4 and the lagging-strand polymerase (Pol) α-primase are behind the helicase. This unexpected architecture indicates that the leading-strand DNA travels a long distance before reaching Pol ɛ, first threading through the Mcm2-7 ring and then making a U-turn at the bottom and reaching Pol ɛ at the top of CMG. Our work reveals an unexpected configuration of the eukaryotic replisome, suggests possible reasons for this architecture and provides a basis for further structural and biochemical replisome studies."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3113"xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "O'Donnell M.E."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/author | "Georgescu R.E."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/pages | "976-982"xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/title | "The architecture of a eukaryotic replisome."xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/26524492 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26524492 |
| http://purl.uniprot.org/citations/26524492 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26524492 |
| http://purl.uniprot.org/uniprot/Q08032#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P30665#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P29496#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P29469#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P24279#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P38132#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/P53091#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |
| http://purl.uniprot.org/uniprot/Q12146#attribution-E5B9407B3D4E8D18EC865B9926FE2451 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26524492 |