| http://purl.uniprot.org/citations/26526998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26526998 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.09.072"xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Patel A."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Moro C."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Martins J.R."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Retailleau K."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Jodar M."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Peyronnet R."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Duprat F."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Demolombe S."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Honore E."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Arhatte M."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/author | "Ranade S.S."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/pages | "1161-1171"xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/title | "Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling."xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/26526998 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26526998 |
| http://purl.uniprot.org/citations/26526998 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26526998 |
| http://purl.uniprot.org/uniprot/#_A0A668KLG7-mappedCitation-26526998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26526998 |
| http://purl.uniprot.org/uniprot/#_B9EKP5-mappedCitation-26526998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26526998 |