| http://purl.uniprot.org/citations/26544937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26544937 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nucleoskeleton, and cytoskeleton (LINC) complex and dynamic microtubules. The data further demonstrate that the excursions promote non-homologous end joining of dysfunctional telomeres and implicated Nesprin-4 and kinesins in telomere fusion. 53BP1/LINC/microtubule-dependent mobility is also evident at irradiation-induced DSBs and contributes to the mis-rejoining of drug-induced DSBs in BRCA1-deficient cells showing that DSB mobility can be detrimental in cells with numerous DSBs. In contrast, under physiological conditions where cells have only one or a few lesions, DSB mobility is proposed to prevent errors in DNA repair."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.09.057"xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/author | "de Lange T."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/author | "Karssemeijer R.A."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/author | "Lottersberger F."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/author | "Dimitrova N."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/pages | "880-893"xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/title | "53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair."xsd:string |
| http://purl.uniprot.org/citations/26544937 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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