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Background

As an important member of the steroid nuclear receptor family, recent research has suggested that PXR may play important roles in the development of multiple cancers. However, no well-designed studies has been conducted to investigate the associations between genetic polymorphisms of PXR and colorectal cancer (CRC) risk in Chinese populations.

Materials and methods

We performed a hospital-based case-control analysis to assess two genetic polymorphisms in the 3'-untranslated regions (3'-UTR) via allele-specific MALDI-TOF mass spectrometry assay and evaluated the associations between two polymorphisms and risk of CRC.

Results

The PXR rs3814058C>T polymorphism was significantly associated with a higher risk of CRC (P<10-3), and the CT/TT variant genotypes had an increased CRC risk (adjusted odds ratio=1.54, 95% confidence interval=1.27-1.83) comparing CC genotype. In stratified analyses, rs3814058CT+TT genotypes was associated with increased risk among alcohol consumers (P=0.002). In vitro experiments indicated that the rs3814058C to rs3814058T transition gained a new binding of the microRNA hsa-miR-129-5p and decreased the PXR expression.

Conclusions

Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR of PXR may be a functional biomarker to predict risk of CRC."xsd:string
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http://purl.uniprot.org/citations/26547791http://purl.uniprot.org/core/author"Pan L."xsd:string
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http://purl.uniprot.org/citations/26547791http://purl.uniprot.org/core/title"Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations."xsd:string
http://purl.uniprot.org/citations/26547791http://purl.uniprot.org/core/volume"39"xsd:string
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