| http://purl.uniprot.org/citations/26549447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26549447 | http://www.w3.org/2000/01/rdf-schema#comment | "During spermatogenesis, the paternal genome is repackaged into a non-nucleosomal, highly compacted chromatin structure. Bioinformatic analysis revealed that Drosophila sperm chromatin proteins are characterized by a motif related to the high-mobility group (HMG) box, which we termed male-specific transcript (MST)-HMG box. MST77F is a MST-HMG-box protein that forms an essential component of sperm chromatin. The deposition of MST77F onto the paternal genome requires the chaperone function of tNAP, a testis-specific NAP protein. MST77F, in turn, enables the stable incorporation of MST35Ba and MST35Bb into sperm chromatin. Following MST-HMG-box protein deposition, the ATP-dependent chromatin remodeler ISWI mediates the appropriate organization of sperm chromatin. Conversely, at fertilization, maternal ISWI targets the paternal genome and drives its repackaging into de-condensed nucleosomal chromatin. Failure of this transition in ISWI mutant embryos is followed by mitotic defects, aneuploidy, and haploid embryonic divisions. Thus, ISWI enables bi-directional transitions between two fundamentally different forms of chromatin."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.10.010"xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Verrijzer C.P."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Moshkin Y.M."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Demmers J.A."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Bezstarosti K."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Doyen C.M."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Chalkley G.E."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/author | "Voets O."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/pages | "1310-1318"xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/title | "A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome."xsd:string |
| http://purl.uniprot.org/citations/26549447 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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