| http://purl.uniprot.org/citations/26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26553808 | http://www.w3.org/2000/01/rdf-schema#comment | "RNase Z(L) is a highly conserved tRNA 3'-end processing endoribonuclease. Similar to its mammalian counterpart, Drosophila RNase Z(L) (dRNaseZ) has a mitochondria targeting signal (MTS) flanked by two methionines at the N-terminus. Alternative translation initiation yields two protein forms: the long one is mitochondrial, and the short one may localize in the nucleus or cytosol. Here, we have generated a mitochondria specific knockout of the dRNaseZ gene. In this in vivo model, cells deprived of dRNaseZ activity display impaired mitochondrial polycistronic transcript processing, increased reactive oxygen species (ROS) and a switch to aerobic glycolysis compensating for cellular ATP. Damaged mitochondria impose a cell cycle delay at the G2 phase disrupting cell proliferation without affecting cell viability. Antioxidants attenuate genotoxic stress and rescue cell proliferation, implying a critical role for ROS. We suggest that under a low-stress condition, ROS activate tumor suppressor p53, which modulates cell cycle progression and promotes cell survival. Transcriptional profiling of p53 targets confirms upregulation of antioxidant and cycB-Cdk1 inhibitor genes without induction of apoptotic genes. This study implicates Drosophila RNase Z(L) in a novel retrograde signaling pathway initiated by the damage in mitochondria and manifested in a cell cycle delay before the mitotic entry."xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkv1149"xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/author | "Dubrovsky E.B."xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/pages | "10364-10375"xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/title | "Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/26553808 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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| http://purl.uniprot.org/uniprot/Q8MKW7#attribution-E1CD4054BE685AF7CC9719CAB4B659B7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26553808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7P1-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
| http://purl.uniprot.org/uniprot/#_A4V4L0-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
| http://purl.uniprot.org/uniprot/#_A1Z6W5-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
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| http://purl.uniprot.org/uniprot/#_P18929-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
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| http://purl.uniprot.org/uniprot/#_P18932-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
| http://purl.uniprot.org/uniprot/#_P18933-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |
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| http://purl.uniprot.org/uniprot/#_P03896-mappedCitation-26553808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26553808 |