| http://purl.uniprot.org/citations/26556536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26556536 | http://www.w3.org/2000/01/rdf-schema#comment | "In comparison with young females, middle-aged female rats sustain greater cerebral infarction and worse functional recovery after stroke. These poorer stroke outcomes in middle-aged females are associated with an age-related reduction in IGF-I levels. Poststroke IGF-I treatment decreases infarct volume in older females and lowers the expression of cytokines in the ischemic hemisphere. IGF-I also reduces transfer of Evans blue dye to the brain, suggesting that this peptide may also promote blood-brain barrier function. To test the hypothesis that IGF-I may act at the blood-brain barrier in ischemic stroke, 2 approaches were used. In the first approach, middle-aged female rats were subjected to middle cerebral artery occlusion and treated with IGF-I after reperfusion. Mononuclear cells from the ischemic hemisphere were stained for CD4 or triple-labeled for CD4/CD25/FoxP3 and subjected to flow analyses. Both cohorts of cells were significantly reduced in IGF-I-treated animals compared with those in vehicle controls. Reduced trafficking of immune cells to the ischemic site suggests that blood-brain barrier integrity is better maintained in IGF-I-treated animals. The second approach directly tested the effect of IGF-I on barrier function of aging endothelial cells. Accordingly, brain microvascular endothelial cells from middle-aged female rats were cultured ex vivo and subjected to ischemic conditions (oxygen-glucose deprivation). IGF-I treatment significantly reduced the transfer of fluorescently labeled BSA across the endothelial monolayer as well as cellular internalization of fluorescein isothiocyanate-BSA compared with those in vehicle-treated cultures, Collectively, these data support the hypothesis that IGF-I improves blood-brain barrier function in middle-aged females."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2015-1840"xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/author | "Alaniz R.C."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/author | "Sohrabji F."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/author | "Bake S."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/author | "Okoreeh A.K."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/pages | "61-69"xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/title | "Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats."xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://purl.uniprot.org/core/volume | "157"xsd:string |
| http://purl.uniprot.org/citations/26556536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26556536 |
| http://purl.uniprot.org/citations/26556536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26556536 |
| http://purl.uniprot.org/uniprot/#_A6JBU4-mappedCitation-26556536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/#_A6JBU5-mappedCitation-26556536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/#_A6JBU6-mappedCitation-26556536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/#_P24062-mappedCitation-26556536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/P24062 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/A6JBU5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/A6JBU4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26556536 |
| http://purl.uniprot.org/uniprot/A6JBU6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26556536 |