| http://purl.uniprot.org/citations/26556542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26556542 | http://www.w3.org/2000/01/rdf-schema#comment | "Invasion and migration of glioblastoma multiforme (GBM) is a multistep process and an important phenotype that causes this disease to invade surrounding tissues in the brain. The purpose of this study was to determine the role of miR-590-3p in regulation of epithelial mesenchymal transition (EMT) and metastasis of GBM cells. Expression levels of miR-590-3p in 15 GBM specimens with adjacent tissues and five GBM cell lines were assessed by quantitative RT-PCR. We found that miR-590-3p was down-regulated in detected GBM tissue samples and all of the GBM cell lines. In addition, Ectopic expression of miR-590-3p suppressed and miR-590-3p-in promoted EMT, migration, and invasion in U87MG and A172 cells. Bioinformatics coupled with luciferase and Western blot assays also revealed that miR-590-3p inhibited expression of ZEB1 and ZEB2, which are master regulators of tumor metastasis. Our study first indicates that miR-590-3p functions as a suppressor of GBM EMT and metastasis by targeting ZEB1 and ZEB2, and it may be a therapeutic target for metastatic GBM."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.11.025"xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/author | "Pang H."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/author | "Xiu X."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/pages | "739-745"xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/title | "miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2."xsd:string |
| http://purl.uniprot.org/citations/26556542 | http://purl.uniprot.org/core/volume | "468"xsd:string |
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