| http://purl.uniprot.org/citations/26561648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26561648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26561648 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic δ-cells. NST has been shown to increase glucagon secretion from primary rat pancreatic islets in low-glucose conditions. Here, we demonstrate that NST increases proglucagon message in α-cells and identify a potential mechanism for NST's cellular activities, including the phosphorylation of PKA following activation of the G protein-coupled receptor, GPR107. GPR107 is abundantly expressed in the pancreas, particularly, in rodent and human α-cells. Compromise of GPR107 in pancreatic α-cells results in failure of NST to increase PKA phosphorylation and proglucagon mRNA levels. We also demonstrate colocalization of GPR107 and NST on both mouse and human pancreatic α-cells. Taken together with our group's observation that NST infusion in conscious rats impairs glucose clearance in response to a glucose challenge and that plasma levels of the peptide are elevated in the fasted compared with the fed or fasted-refed state, these studies support the hypothesis that endogenous NST regulates islet cell function by interacting with GPR107 and initiating signaling in glucagon-producing α-cells."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00369.2014"xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00369.2014"xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Samson W.K."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Samson W.K."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Corbett J.A."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Corbett J.A."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Elrick M.M."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Elrick M.M."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Kolar G.R."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Kolar G.R."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Naatz A."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Naatz A."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Salvatori A.S."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Salvatori A.S."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Stein L.M."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Stein L.M."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Yosten G.L."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/author | "Yosten G.L."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/26561648 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |