| http://purl.uniprot.org/citations/26563484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26563484 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Myc protein is dysregulated in many human cancers and its function has not been fully elucitated yet. The c-Myc inhibitor Omomyc displays potent anticancer properties in animal models. It perturbs the c-Myc protein network, impairs c-Myc binding to the E-boxes, retaining transrepressive properties and inducing histone deacetylation. Here we have employed Omomyc to further analyse c-Myc activity at the epigenetic level. We show that both Myc and Omomyc stimulate histone H4 symmetric dimethylation of arginine (R) 3 (H4R3me2s), in human glioblastoma and HEK293T cells. Consistently, both associated with protein Arginine Methyltransferase 5 (PRMT5)--the catalyst of the reaction--and its co-factor Methylosome Protein 50 (MEP50). Confocal experiments showed that Omomyc co-localized with c-Myc, PRMT5 and H4R3me2s-enriched chromatin domains. Finally, interfering with PRMT5 activity impaired target gene activation by Myc whereas it restrained Omomyc-dependent repression. The identification of a histone-modifying complex associated with Omomyc represents the first demonstration of an active role of this miniprotein in modifying chromatin structure and adds new information regarding its action on c-Myc targets. More importantly, the observation that c-Myc may recruit PRMT5-MEP50, inducing H4R3 symmetric di-methylation, suggests previously unpredictable roles for c-Myc in gene expression regulation and new potential targets for therapy."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep15494"xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Levi A."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Illi B."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Savino M."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Nasi S."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Farsetti A."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Falchetti M.L."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Favia A."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Nanni S."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Mongiardi M.P."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Bartoli L."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Beji S."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/author | "Scagnoli F."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/pages | "15494"xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/title | "Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26563484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26563484 |
| http://purl.uniprot.org/citations/26563484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26563484 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-26563484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26563484 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-26563484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26563484 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-26563484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26563484 |