| http://purl.uniprot.org/citations/26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26565905 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates mesodermal specification and determination. Ablation of Dicer in the Etv2-expressing precursors resulted in altered mesodermal lineages and embryonic lethality. We identified miR-130a as a direct target of Etv2 and demonstrated its role in the segregation of bipotent hemato-endothelial progenitors toward the endothelial lineage. Gain-of-function experiments demonstrated that miR-130a promoted the endothelial program at the expense of the cardiac program without impacting the hematopoietic lineages. In contrast, CRISPR/Cas9-mediated knockout of miR-130a demonstrated a reduction of the endothelial program without affecting hematopoiesis. Mechanistically, miR-130a directly suppressed Pdgfra expression and promoted the endothelial program by blocking Pdgfra signaling. Inhibition or activation of Pdgfra signaling phenocopied the miR-130a overexpression and knockout phenotypes, respectively. In summary, we report the function of a miRNA that specifically promotes the divergence of the hemato-endothelial progenitor to the endothelial lineage."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.09.060"xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Gong W."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Singh B.N."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Garry D.J."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Garry M.G."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Koyano-Nakagawa N."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Rasmussen T.L."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/author | "Akiyama R."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/pages | "915-923"xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/title | "The Etv2-miR-130a Network Regulates Mesodermal Specification."xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/26565905 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26565905 |
| http://purl.uniprot.org/citations/26565905 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26565905 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJD6-mappedCitation-26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26565905 |
| http://purl.uniprot.org/uniprot/#_A0A8F5XVB9-mappedCitation-26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26565905 |
| http://purl.uniprot.org/uniprot/#_A0A8I4YZW9-mappedCitation-26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26565905 |
| http://purl.uniprot.org/uniprot/#_F8VQ54-mappedCitation-26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26565905 |
| http://purl.uniprot.org/uniprot/#_P35918-mappedCitation-26565905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26565905 |