| http://purl.uniprot.org/citations/26571504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26571504 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes. Protein modification by ubiquitination is involved in this pathway: it regulates the stability of autophagy regulators such as BECLIN-1 and it also functions as a tag targeting specific substrates to autophagosomes. In order to identify deubiquitinating enzymes (DUBs) involved in autophagy, we have performed a genetic screen in the Drosophila larval fat body. This screen identified Uch-L3, Usp45, Usp12 and Ubpy. In this paper, we show that Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux. Furthermore, analysis by electron and confocal microscopy of Ubpy-depleted fat body cells revealed altered lysosomal morphology, indicating that Ubpy inactivation affects lysosomal maintenance and/or biogenesis. Lastly, we have shown that shRNA mediated inactivation of UBPY in HeLa cells affects autophagy in a different way: in UBPY-depleted HeLa cells autophagy is deregulated."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0143078"xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Schoehn G."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Fauvarque M.O."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Gallet B."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Taillebourg E."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Jacomin A.C."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Bescond A."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/author | "Soleilhac E."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/pages | "e0143078"xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/title | "The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26571504 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26571504 |
| http://purl.uniprot.org/citations/26571504 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26571504 |
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