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http://purl.uniprot.org/citations/26573599http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26573599http://www.w3.org/2000/01/rdf-schema#comment"

Background

The vasoconstricting peptide endothelin-1 has been proposed to be a marker of cardiovascular disease. Our aim was to investigate whether circulating endothelin-1 levels predict coronary heart disease (CHD) in Sweden.

Methods

In 2002-2005, 2816 adult participants (30-74 years) were randomly selected from two municipalities in south-western Sweden. Cardiovascular risk factors and endothelin-1 levels were assessed at baseline, and incident CHD was followed-up in all participants through 2011. After exclusion of 50 participants due to known CHD at baseline and 21 participants because of unsuccessful analysis of endothelin-1, 2745 participants were included in the study. In total, 72 CHD events (52 in men and 20 in women) were registered during the follow-up time.

Results

We showed that baseline circulating endothelin-1 levels were higher in women with incident CHD than in women without CHD (3.2 pg/ml, SE: 0.36 vs 2.4 pg/ml, SE: 0.03, p = 0.003) whereas this difference was not observed in men (2.3 pg/ml, SE: 0.16 vs 2.3 pg/ml, SE: 0.04, p = 0.828). An age-adjusted Cox proportional regression analysis showed an enhanced risk of CHD with increasing baseline endothelin-1 levels in women (hazard ratio (HR) = 1.51, 95 % CI = 1.1-2.1, p = 0.015) but not in men (HR = 0.98, 95 % CI = 0.8-1.2, p = 0.854). Furthermore, the predictive value of endothelin-1 for incident CHD in women was still significant after adjustments for age, HOMA-IR, apolipoprotein (apo)B/apoA1 and smoking (HR = 1.53, CI = 1.1-1.2, p = 0.024).

Conclusion

Circulating endothelin-1 levels may predict CHD in women."xsd:string
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http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Olausson J."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Lindblad U."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Rastam L."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Larsson C.A."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Jansson P.A."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Daka B."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/author"Hellgren M.I."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/name"BMC Cardiovasc Disord"xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/pages"146"xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/title"Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skovde Cohort."xsd:string
http://purl.uniprot.org/citations/26573599http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/26573599http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26573599
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