| http://purl.uniprot.org/citations/26580398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26580398 | http://www.w3.org/2000/01/rdf-schema#comment | "Childhood acute lymphoblastic leukemia (ALL) with t(12;21), which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B) ALL. We identified 17 microRNAs that were downregulated in ETV6/RUNX1+ compared with ETV6/RUNX1-clinical samples. Among these microRNAs, miR-181a-1 was the most significantly reduced (by ~75%; P < 0.001). Using chromatin immunoprecipitation, we demonstrated that ETV6/RUNX1 directly binds the regulatory region of MIR181A1, and knockdown of ETV6/RUNX1 increased miR-181a-1 level. We further showed that miR-181a (functional counterpart of miR-181a-1) could target ETV6/RUNX1 and cause a reduction in the level of the oncoprotein ETV6/RUNX1, cell growth arrest, an increase in apoptosis, and induction of cell differentiation in ETV6/RUNX1+ cell line. Moreover, ectopic expression of miR-181a also resulted in decreased CD10 hyperexpression in ETV6/RUNX1+ primary patient samples. Taken together, our results demonstrate that MIR181A1 and ETV6/RUNX1 regulate each other, and we propose that a double negative loop involving MIR181A1 and ETV6/RUNX1 may contribute to ETV6/RUNX1-driven arrest of differentiation in pre-B ALL."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0142863"xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Chen H.Y."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Lin S.W."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Yu S.L."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Lin D.T."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Lin S.R."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Yang Y.L."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Pai C.H."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Hu C.Y."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Yen C.T."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/author | "Jou S.T."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/pages | "e0142863"xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/title | "A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia."xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26580398 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26580398 |
| http://purl.uniprot.org/citations/26580398 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26580398 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG58-mappedCitation-26580398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26580398 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3N6-mappedCitation-26580398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26580398 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3C9-mappedCitation-26580398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26580398 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5DI34-mappedCitation-26580398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26580398 |