| http://purl.uniprot.org/citations/26581065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26581065 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundDuring conservative treatment, congenital hyperinsulinism (CHI) can resolve spontaneously. This study describes the hormonal and metabolic profiles in three patients with ABCC8/KCNJ11 mutations in clinical remission.MethodsAn age-adapted fasting and oral glucose tolerance test (OGTT) were performed.ResultsAll patients (aged 6-9 years) tolerated age-adapted fasting durations (20, respectively 24 h), without reaching glucose concentrations ≤2.5 mmol/L, nor developing hypoglycemia-related symptoms. Nevertheless, insulin concentrations from all patients exceeded the 90th reference percentile at the end of the fasting test (range: 4.2-15.8 mU/L). During the OGTT, one patient (patient 2; BMI: 23.4 kg/m2; age: 7 years) reached a glucose concentration of 11.4 mmol/L after 2 h (concomitant insulin concentration: 148.3 mU/L).ConclusionsThe insulin concentration profiles in CHI patients in apparent clinical remission range from almost complete normalization to persistent, yet attenuated, hypersecretion. The hyperglycemia, detected during the OGTT, must be further monitored."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.org/dc/terms/identifier | "doi:10.1515/jpem-2015-0192"xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Mayatepek E."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Meissner T."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Kummer S."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Wieland I."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Zenker M."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Welters A."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Doing C."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Lachmann M.J."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/author | "Salgin B."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/name | "J Pediatr Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/pages | "281-287"xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/title | "Remission of congenital hyperinsulinism following conservative treatment: an exploratory study in patients with KATP channel mutations."xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/26581065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26581065 |
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