| http://purl.uniprot.org/citations/26581405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26581405 | http://www.w3.org/2000/01/rdf-schema#comment | "We generate a mouse model for the human microcephaly syndrome by mutating the ASPM locus, and demonstrate a premature exhaustion of the neuronal progenitor pool due to dysfunctional self-renewal processes. Earlier studies have linked ASPM mutant progenitor excessive cell cycle exit to a mitotic orientation defect. Here, we demonstrate a mitotic orientation-independent effect of ASPM on cell cycle duration. We pinpoint the cell fate-determining factor to the length of time spent in early G1 before traversing the restriction point. Characterization of the molecular mechanism reveals an interaction between ASPM and the Cdk2/Cyclin E complex, regulating the Cyclin activity by modulating its ubiquitination, phosphorylation and localization into the nucleus, before the cell is fated to transverse the restriction point. Thus, we reveal a novel function of ASPM in mediating the tightly coordinated Ubiquitin- Cyclin E-Retinoblastoma-E2F bistable-signalling pathway controlling restriction point progression and stem cell maintenance."xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9763"xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/author | "Capecchi M.R."xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/author | "Pozner A."xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/pages | "8763"xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/title | "ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/26581405 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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