| http://purl.uniprot.org/citations/26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26581893 | http://www.w3.org/2000/01/rdf-schema#comment | "Generation of β-amyloid (Aβ) peptide in Alzheimer's disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific modulators for γ-secretase could be a potential avenue to treat the disease. Here, we report that transient receptor potential canonical (TRPC) 6 specifically interacts with APP leading to inhibition of its cleavage by γ-secretase and reduction in Aβ production. TRPC6 interacts with APP (C99), but not with Notch, and prevents C99 interaction with presenilin 1 (PS1). A fusion peptide derived from TRPC6 also reduces Aβ levels without effect on Notch cleavage. Crossing APP/PS1 mice with TRPC6 transgenic mice leads to a marked reduction in both plaque load and Aβ levels, and improvement in structural and behavioural impairment. Thus, TRPC6 specifically modulates γ-secretase cleavage of APP and preventing APP (C99) interaction with PS1 via TRPC6 could be a novel strategy to reduce Aβ formation."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9876"xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "He Z."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Lu R."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/author | "Jing N."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/pages | "8876"xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/title | "TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production."xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26581893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26581893 |
| http://purl.uniprot.org/citations/26581893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26581893 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_A0A140VJC8-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_A0A218KGR2-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_A0A8F9R5D5-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_B4DGD0-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_B3KNL3-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |
| http://purl.uniprot.org/uniprot/#_B4DMD5-mappedCitation-26581893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26581893 |