| http://purl.uniprot.org/citations/26585400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26585400 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12(+) endothelial cells and Cxcr4(+) gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing targets within the neoplastic gastric stem cell niche."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2015.10.003"xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Kim W."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Takemoto Y."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Shen Z."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Fox J.G."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Gershon M.D."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Hara A."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Tomita H."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Saha S."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Wang T.C."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Worthley D.L."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Friedman R.A."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Korinek V."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Konieczny S.F."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Sepulveda A.R."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Shibata W."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Tailor Y."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Ariyama H."xsd:string |
| http://purl.uniprot.org/citations/26585400 | http://purl.uniprot.org/core/author | "Asfaha S."xsd:string |