| http://purl.uniprot.org/citations/26586219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26586219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26586219 | http://www.w3.org/2000/01/rdf-schema#comment | "C. elegans embryonic elongation is a morphogenetic event driven by actomyosin contractility and muscle-induced tension transmitted through hemidesmosomes. A role for the microtubule cytoskeleton has also been proposed, but its contribution remains poorly characterized. Here, we investigate the organization of the non-centrosomal microtubule arrays present in the epidermis and assess their function in elongation. We show that the microtubule regulators γ-tubulin and NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongation. Several parallel approaches suggest that microtubule nucleation occurs from these sites. Disrupting the epidermal microtubule array by overexpressing the microtubule-severing protein Spastin or by inhibiting the C. elegans ninein homolog NOCA-1 in the epidermis mildly affected elongation. However, microtubules were essential for elongation when hemidesmosomes or the activity of the Rho kinase LET-502/ROCK were partially compromised. Imaging of junctional components and genetic analyses suggest that epidermal microtubules function together with Rho kinase to promote the transport of E-cadherin to adherens junctions and myotactin to hemidesmosomes. Our results indicate that the role of LET-502 in junctional remodeling is likely to be independent of its established function as a myosin II activator, but requires a microtubule-dependent pathway involving the syntaxin SYX-5. Hence, we propose that non-centrosomal microtubules organized by epidermal junctions contribute to elongation by transporting junction remodeling factors, rather than having a mechanical role."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126615"xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126615"xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Quintin S."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Quintin S."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Hyenne V."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Hyenne V."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Bender A."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Bender A."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Labouesse M."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Labouesse M."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Gally C."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Gally C."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Landmann F."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Landmann F."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Pontabry J."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Pontabry J."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Robin F."xsd:string |
| http://purl.uniprot.org/citations/26586219 | http://purl.uniprot.org/core/author | "Robin F."xsd:string |