| http://purl.uniprot.org/citations/26586441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26586441 | http://www.w3.org/2000/01/rdf-schema#comment | "Maternal genomic imprints are established during oogenesis. Histone deacetylases (HDACs) 1 and 2 are required for oocyte development in mouse, but their role in genomic imprinting is unknown. We find that Hdac1:Hdac2(-/-) double-mutant growing oocytes exhibit global DNA hypomethylation and fail to establish imprinting marks for Igf2r, Peg3, and Srnpn. Global hypomethylation correlates with increased retrotransposon expression and double-strand DNA breaks. Nuclear-associated DNMT3A2 is reduced in double-mutant oocytes, and injecting these oocytes with Hdac2 partially restores DNMT3A2 nuclear staining. DNMT3A2 co-immunoprecipitates with HDAC2 in mouse embryonic stem cells. Partial loss of nuclear DNMT3A2 and HDAC2 occurs in Sin3a(-/-) oocytes, which exhibit decreased DNA methylation of imprinting control regions for Igf2r and Srnpn, but not Peg3. These results suggest seminal roles of HDAC1/2 in establishing maternal genomic imprints and maintaining genomic integrity in oocytes mediated in part through a SIN3A complex that interacts with DNMT3A2."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.10.031"xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/author | "Ma P."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/author | "Weaver J.R."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/author | "Schultz R.M."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/author | "Bartolomei M.S."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/author | "de Waal E."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/pages | "1552-1560"xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/title | "A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes."xsd:string |
| http://purl.uniprot.org/citations/26586441 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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