| http://purl.uniprot.org/citations/26593424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26593424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26593424 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs containing N(6)-methyladenosine (m(6)A) in their 5' UTR can be translated in a cap-independent manner. A single 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficient to recruit the 43S complex to initiate translation in the absence of the cap-binding factor eIF4E. Inhibition of adenosine methylation selectively reduces translation of mRNAs containing 5'UTR m(6)A. Additionally, increased m(6)A levels in the Hsp70 mRNA regulate its cap-independent translation following heat shock. Notably, we find that diverse cellular stresses induce a transcriptome-wide redistribution of m(6)A, resulting in increased numbers of mRNAs with 5' UTR m(6)A. These data show that 5' UTR m(6)A bypasses 5' cap-binding proteins to promote translation under stresses."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.012"xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.012"xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Qian S.B."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Qian S.B."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Pestova T.V."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Pestova T.V."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Skabkin M.A."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Skabkin M.A."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Jaffrey S.R."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Jaffrey S.R."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Zinoviev A."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Zinoviev A."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Elemento O."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Elemento O."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Patil D.P."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Patil D.P."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Meyer K.D."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/author | "Meyer K.D."xsd:string |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26593424 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |