DESCRIBE <http://purl.uniprot.org/citations/26602865>

Subject	Predicate	Object
http://purl.uniprot.org/citations/26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26602865	http://www.w3.org/2000/01/rdf-schema#comment	" Rationale Caveolin-1 (Cav-1) negatively regulates endothelial nitric oxide (NO) synthase-derived NO production, and this has been mapped to several residues on Cav-1, including F92. Herein, we reasoned that endothelial expression of an F92ACav-1 transgene would let us decipher the mechanisms and relationships between caveolae structure and intracellular signaling. Objective This study was designed to separate caveolae formation from its downstream signaling effects. Methods and results An endothelial-specific doxycycline-regulated mouse model for the expression of Cav-1-F92A was developed. Blood pressure by telemetry and nitric oxide bioavailability by electron paramagnetic resonance and phosphorylation of vasodilator-stimulated phosphoprotein were determined. Caveolae integrity in the presence of Cav-1-F92A was measured by stabilization of caveolin-2, sucrose gradient, and electron microscopy. Histological analysis of heart and lung, echocardiography, and signaling were performed. Conclusions This study shows that mutant Cav-1-F92A forms caveolae structures similar to WT but leads to increases in NO bioavailability in vivo, thereby demonstrating that caveolae formation and downstream signaling events occur through independent mechanisms."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.org/dc/terms/identifier	"doi:10.1161/circresaha.115.307767"xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Hao Z."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Liu X."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Kraehling J.R."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Sessa W.C."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Velazquez H."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Lee M.Y."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Brudvig G.W."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Stan R.V."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/author	"Vinyard D.J."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/date	"2016"xsd:gYear
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/name	"Circ Res"xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/pages	"48-55"xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/title	"Uncoupling Caveolae From Intracellular Signaling In Vivo."xsd:string
http://purl.uniprot.org/citations/26602865	http://purl.uniprot.org/core/volume	"118"xsd:string
http://purl.uniprot.org/citations/26602865	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/26602865
http://purl.uniprot.org/citations/26602865	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/26602865
http://purl.uniprot.org/uniprot/#_A9XTE5-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865
http://purl.uniprot.org/uniprot/#_Q71VB8-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865
http://purl.uniprot.org/uniprot/#_Q2TNI1-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865
http://purl.uniprot.org/uniprot/#_Q03135-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865
http://purl.uniprot.org/uniprot/#_Q59E85-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865
http://purl.uniprot.org/uniprot/#_Q7Z4F3-mappedCitation-26602865	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26602865