| http://purl.uniprot.org/citations/26602884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26602884 | http://www.w3.org/2000/01/rdf-schema#comment | "Extremely low-frequency electromagnetic field (ELFEF) is a well-known mechanical stimulation that induces neural differentiation. It is potentially an effective treatment for neurodegenerative diseases. In a previous study, ferritin light chain was upregulated in ELFEF-exposed human bone marrow-derived mesenchymal stem cells (BM-MSCs). Ferritin light chain is a component of ferritin, a highly conserved iron-binding protein. In this study, to identify molecules associated with ferritin during neural differentiation of BM-MSCs, we performed reverse transcription polymerase chain reaction (RT-PCR), western blotting, and ATP analysis. Our data indicated that ELFEF triggers the upregulation of ferritin light chain (FLC) and ferritin heavy chain (FHC) in BM-MSCs. The elevated levels of FLC and FHC correlated positively with the differentiation of BM-MSCs into neural cells. Moreover ELFEF induced the activation of iron regulatory protein-1 (IRP-1) and cofilin, which are downstream targets of ferritin. These results suggest that ELFEF induces neural differentiation through activation of a ferritin-regulated mechanism."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/author | "Kim C.W."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/author | "Lee H.N."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/author | "Ko K.N."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/author | "Rosebud Aikins A."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/name | "Cell Mol Biol (Noisy-le-grand)"xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/pages | "55-59"xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/title | "Ferritin is associated with neural differentiation of bone marrow-derived mesenchymal stem cells under extremely low-frequency electromagnetic field."xsd:string |
| http://purl.uniprot.org/citations/26602884 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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