| http://purl.uniprot.org/citations/26607792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26607792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26607792 | http://www.w3.org/2000/01/rdf-schema#comment | "Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 methylation is necessary to silence and to anchor repeat-rich heterochromatin at the nuclear periphery. In a screen for perinuclear anchors of heterochromatin, we identified a previously uncharacterized C. elegans chromodomain protein, CEC-4. CEC-4 binds preferentially mono-, di-, or tri-methylated H3K9 and localizes at the nuclear envelope independently of H3K9 methylation and nuclear lamin. CEC-4 is necessary for endogenous heterochromatin anchoring, but not for transcriptional repression, in contrast to other known H3K9 methyl-binders in worms, which mediate gene repression but not perinuclear anchoring. When we ectopically induce a muscle differentiation program in embryos, cec-4 mutants fail to commit fully to muscle cell fate. This suggests that perinuclear sequestration of chromatin during development helps restrict cell differentiation programs by stabilizing commitment to a specific cell fate. PAPERCLIP."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.066"xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.066"xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Geng L."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Geng L."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gaidatzis D."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gaidatzis D."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Kalck V."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Kalck V."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gasser S.M."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gasser S.M."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Cabianca D.S."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Cabianca D.S."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gonzalez-Sandoval A."xsd:string |
| http://purl.uniprot.org/citations/26607792 | http://purl.uniprot.org/core/author | "Gonzalez-Sandoval A."xsd:string |