| http://purl.uniprot.org/citations/26619264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26619264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26619264 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosome synthesis is catalyzed by ∼200 assembly factors, which facilitate efficient production of mature ribosomes. Here, we determined the cryo-EM structure of a Saccharomyces cerevisiae nucleoplasmic pre-60S particle containing the dynein-related 550-kDa Rea1 AAA(+) ATPase and the Rix1 subcomplex. This particle differs from its preceding state, the early Arx1 particle, by two massive structural rearrangements: an ∼180° rotation of the 5S ribonucleoprotein complex and the central protuberance (CP) rRNA helices, and the removal of the 'foot' structure from the 3' end of the 5.8S rRNA. Progression from the Arx1 to the Rix1 particle was blocked by mutational perturbation of the Rix1-Rea1 interaction but not by a dominant-lethal Rea1 AAA(+) ATPase-ring mutant. After remodeling, the Rix1 subcomplex and Rea1 become suitably positioned to sense correct structural maturation of the CP, which allows unidirectional progression toward mature ribosomes."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3132"xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3132"xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Flemming D."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Flemming D."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Thoms M."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Thoms M."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Bassler J."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Bassler J."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Barrio-Garcia C."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Barrio-Garcia C."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Kater L."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/author | "Kater L."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/26619264 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |