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http://purl.uniprot.org/citations/26620207http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26620207http://www.w3.org/2000/01/rdf-schema#comment"

Aim

The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS).

Method

We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction.

Results

We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients.

Conclusion

This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.org/dc/terms/identifier"doi:10.1111/1756-185x.12804"xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/author"Chen J.Q."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/author"Papp G."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/author"Zilahi E."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/author"Sipka S."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/author"Zeher M."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/name"Int J Rheum Dis"xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/pages"609-613"xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/title"Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjogren's syndrome."xsd:string
http://purl.uniprot.org/citations/26620207http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/26620207http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26620207
http://purl.uniprot.org/citations/26620207http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26620207
http://purl.uniprot.org/uniprot/#_O15524-mappedCitation-26620207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26620207
http://purl.uniprot.org/uniprot/#_Q4JHT5-mappedCitation-26620207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26620207
http://purl.uniprot.org/uniprot/O15524http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26620207
http://purl.uniprot.org/uniprot/Q4JHT5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26620207