| http://purl.uniprot.org/citations/26620968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26620968 | http://www.w3.org/2000/01/rdf-schema#comment | "Amelotin (AMTN) and kallikrein-4 (KLK4) are secreted proteins specialized for enamel biomineralization. We characterized enamel from wild-type, Amtn(-/-), Klk4(-/-), Amtn(+/-)Klk4(+/-) and Amtn(-/-)Klk4(-/-) mice to gain insights into AMTN and KLK4 functions during amelogenesis. All of the null mice were healthy and fertile. The mandibular incisors in Amtn(-/-), Klk4(-/-) and Amtn(-/-)Klk4(-/-) mice were chalky-white and chipped. No abnormalities except in enamel were observed, and no significant differences were detected in enamel thickness or volume, or in rod decussation. Micro-computed tomography (μCT) maximum intensity projections localized the onset of enamel maturation in wild-type incisors distal to the first molar, but mesial to this position in Amtn(-/-), Klk4(-/-) and Amtn(-/-)Klk4(-/-) mice, demonstrating a delay in enamel maturation in Amtn(-/-) incisors. Micro-CT detected significantly reduced enamel mineral density (2.5 and 2.4gHA/cm(3)) in the Klk4(-/-) and Amtn(-/-)Klk4(-/-) mice respectively, compared with wild-type enamel (3.1gHA/cm(3)). Backscatter scanning electron microscopy showed that mineral density progressively diminished with enamel depth in the Klk4(-/-) and Amtn(-/-)Klk4(-/-) mice. The Knoop hardness of the Amtn(-/-) outer enamel was significantly reduced relative to the wild-type and was not as hard as the middle or inner enamel. Klk4(-/-) enamel hardness was significantly reduced at all levels, but the outer enamel was significantly harder than the inner and middle enamel. Thus the hardness patterns of the Amtn(-/-) and Klk4(-/-) mice were distinctly different, while the Amtn(-/-)Klk4(-/-) outer enamel was not as hard as in the Amtn(-/-) and Klk4(-/-) mice. We conclude that AMTN and KLK4 function independently, but are both necessary for proper enamel maturation."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2015.11.007"xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Hu J.C."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Simmer J.P."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Ganss B."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Richardson A.S."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Nunez S.M."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Schmitz J.E."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Fajardo R."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/author | "Chun Y.P."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/pages | "219-233"xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/title | "Maturation stage enamel malformations in Amtn and Klk4 null mice."xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://purl.uniprot.org/core/volume | "52-54"xsd:string |
| http://purl.uniprot.org/citations/26620968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26620968 |
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