| http://purl.uniprot.org/citations/26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26624013 | http://www.w3.org/2000/01/rdf-schema#comment | "Autoimmune diabetes is a consequence of immune-cell infiltration and destruction of pancreatic β-cells in the islets of Langerhans. We analyzed the cellular composition of the insulitic lesions in the autoimmune-prone non-obese diabetic (NOD) mouse and observed a peak in recruitment of plasmacytoid dendritic cells (pDCs) to NOD islets around 8-9 weeks of age. This peak coincides with increased spontaneous expression of type-1-IFN response genes and CpG1585 induced production of IFN-α from NOD islets. The transcription factor E2-2 is specifically required for the maturation of pDCs, and we show that knocking out E2-2 conditionally in CD11c+ cells leads to a reduced recruitment of pDCs to pancreatic islets and reduced CpG1585 induced production of IFN-α during insulitis. As a consequence, insulitis has a less aggressive expression profile of the Th1 cytokine IFN-γ and a markedly reduced diabetes incidence. Collectively, these observations demonstrate a disease-promoting role of E2-2 dependent pDCs in the pancreas during autoimmune diabetes in the NOD mouse."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0144090"xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Hansen L."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Santamaria P."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Reizis B."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Holmberg D."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Schmidt-Christensen A."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Fransen-Pettersson N."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/author | "Hannibal T.D."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/pages | "e0144090"xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/title | "E2-2 Dependent Plasmacytoid Dendritic Cells Control Autoimmune Diabetes."xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26624013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26624013 |
| http://purl.uniprot.org/citations/26624013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26624013 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTR9-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTU7-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTW1-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTX3-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU37-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YU89-mappedCitation-26624013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26624013 |