| http://purl.uniprot.org/citations/26628363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26628363 | http://www.w3.org/2000/01/rdf-schema#comment | "APOBEC3 family DNA cytosine deaminases provide overlapping defenses against pathogen infections. However, most viruses have elaborate evasion mechanisms such as the HIV-1 Vif protein, which subverts cellular CBF-β and a polyubiquitin ligase complex to neutralize these enzymes. Despite advances in APOBEC3 and Vif biology, a full understanding of this direct host-pathogen conflict has been elusive. We combine virus adaptation and computational studies to interrogate the APOBEC3F-Vif interface and build a robust structural model. A recurring compensatory amino acid substitution from adaptation experiments provided an initial docking constraint, and microsecond molecular dynamic simulations optimized interface contacts. Virus infectivity experiments validated a long-lasting electrostatic interaction between APOBEC3F E289 and HIV-1 Vif R15. Taken together with mutagenesis results, we propose a wobble model to explain how HIV-1 Vif has evolved to bind different APOBEC3 enzymes and, more generally, how pathogens may evolve to escape innate host defenses."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.10.067"xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Anderson B.D."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Amaro R.E."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Demir O."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Albin J.S."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Harki D.A."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Harris R.S."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Land A.M."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Shaban N.M."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Richards C."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Anderson J.S."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Luengas E.M."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/author | "Holten J.R."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/pages | "1781-1788"xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/title | "The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches."xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/26628363 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26628363 |
| http://purl.uniprot.org/citations/26628363 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26628363 |
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| http://purl.uniprot.org/uniprot/#_B4DGW8-mappedCitation-26628363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26628363 |