| http://purl.uniprot.org/citations/26631730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26631730 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging involves progressive loss of cellular function and integrity, presumably caused by accumulated stochastic damage to cells. Alterations in energy metabolism contribute to aging, but how energy metabolism changes with age, how these changes affect aging, and whether they can be modified to modulate aging remain unclear. In locomotory muscle of post-fertile Caenorhabditis elegans, we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associated metabolic enzyme, and a reciprocal increase in glycolytic pyruvate kinase (PK) that were necessary and sufficient to limit lifespan. Decline in PEPCK-C with age also led to loss of cellular function and integrity including muscle activity, and cellular senescence. Genetic and pharmacologic interventions of PEPCK-C, muscle activity, and AMPK signaling demonstrate that declines in PEPCK-C and muscle function with age interacted to limit reproductive life and lifespan via disrupted energy homeostasis. Quantifications of metabolic flux show that reciprocal changes in PEPCK-C and PK with age shunted energy metabolism toward glycolysis, reducing mitochondrial bioenergetics. Last, calorie restriction countered changes in PEPCK-C and PK with age to elicit anti-aging effects via TOR inhibition. Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.691766"xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Feng Z."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Cao P."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Hang X."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Erzurum S.C."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Xia K."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Hsu A.L."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Kao A."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Kao C."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Boyd-Tressler A."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Dubyak G.R."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Ching T.T."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Hakimi P."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Hanson R.W."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Slater E."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Janocha A."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Berger N.A."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Alhoraibi H."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/author | "Shue Q."xsd:string |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26631730 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |