| http://purl.uniprot.org/citations/26638075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26638075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26638075 | http://www.w3.org/2000/01/rdf-schema#comment | "The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use proximity-dependent biotinylation (BioID) to map the centrosome-cilium interface; with 58 bait proteins we generate a protein topology network comprising >7,000 interactions. Analysis of interaction profiles coupled with high resolution phenotypic profiling implicates a number of protein modules in centriole duplication, ciliogenesis, and centriolar satellite biogenesis and highlights extensive interplay between these processes. By monitoring dynamic changes in the centrosome-cilium protein interaction landscape during ciliogenesis, we also identify satellite proteins that support cilia formation. Systematic profiling of proximity interactions combined with functional analysis thus provides a rich resource for better understanding human centrosome and cilia biology. Similar strategies may be applied to other complex biological structures or pathways."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.065"xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.10.065"xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Raught B."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Raught B."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Hildebrandt F."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Hildebrandt F."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Gupta G.D."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Gupta G.D."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Goncalves J."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Goncalves J."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Moffat J."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Moffat J."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Tkach J.M."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Tkach J.M."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Bashkurov M."xsd:string |
| http://purl.uniprot.org/citations/26638075 | http://purl.uniprot.org/core/author | "Bashkurov M."xsd:string |