| http://purl.uniprot.org/citations/26638174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26638174 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapidly evolving internal transcribed spacer 2 (ITS2) in the pre-ribosomal RNA is one of the most commonly applied phylogenetic markers at species and genus level. Yet, during ribosome biogenesis ITS2 is removed in all eukaryotes by a common, but still unknown, mechanism. Here we describe the existence of an RNA processome, assembled from four conserved subunits, Las1-Grc3-Rat1-Rai1, that carries all the necessary RNA processing enzymes to mediate coordinated ITS2 rRNA removal. Las1 is the long-sought-after endonuclease cleaving 27SB pre-rRNA at site C2 to yield a 5'-OH end at the 26S pre-rRNA and 2',3' cyclic phosphate at the 3' end of 7S pre-rRNA. Subsequently, polynucleotide kinase Grc3 catalyzes ATP-dependent 5'-OH phosphorylation of 26S pre-rRNA, which in turn enables Rat1-Rai1 exonuclease to generate 25S' pre-rRNA. ITS2 processing is reminiscent of tRNA splicing, but instead of subsequent tRNA ligation, the Las1 complex carries along an exonuclease tool to degrade the ITS2 rRNA."xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.10.021"xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/author | "Flemming D."xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/author | "Gasse L."xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/pages | "808-815"xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/title | "Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities."xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/26638174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26638174 |
| http://purl.uniprot.org/citations/26638174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26638174 |
| http://purl.uniprot.org/uniprot/Q07845#attribution-2EB3E708C5DD854FD7A2FD6BD5A2F109 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/Q07845#attribution-9370ED1F5C9BF1D0A7D2425728BBAA86 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/P53063#attribution-2EB3E708C5DD854FD7A2FD6BD5A2F109 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/P53063#attribution-9370ED1F5C9BF1D0A7D2425728BBAA86 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/P36146#attribution-2EB3E708C5DD854FD7A2FD6BD5A2F109 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/P36146#attribution-9370ED1F5C9BF1D0A7D2425728BBAA86 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/Q02792#attribution-2EB3E708C5DD854FD7A2FD6BD5A2F109 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/Q02792#attribution-9370ED1F5C9BF1D0A7D2425728BBAA86 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/#_Q07845-mappedCitation-26638174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/#_P36146-mappedCitation-26638174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/#_P53063-mappedCitation-26638174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26638174 |
| http://purl.uniprot.org/uniprot/#_Q02792-mappedCitation-26638174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26638174 |