| http://purl.uniprot.org/citations/26642365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26642365 | http://www.w3.org/2000/01/rdf-schema#comment | "HDL from healthy humans and lean mice inhibits palmitate-induced adipocyte inflammation; however, the effect of the inflammatory state on the functional properties of HDL on adipocytes is unknown. Here, we found that HDL from mice injected with AgNO3 fails to inhibit palmitate-induced inflammation and reduces cholesterol efflux from 3T3-L1 adipocytes. Moreover, HDL isolated from obese mice with moderate inflammation and humans with systemic lupus erythematosus had similar effects. Since serum amyloid A (SAA) concentrations in HDL increase with inflammation, we investigated whether elevated SAA is a causal factor in HDL dysfunction. HDL from AgNO3-injected mice lacking Saa1.1 and Saa2.1 exhibited a partial restoration of antiinflammatory and cholesterol efflux properties in adipocytes. Conversely, incorporation of SAA into HDL preparations reduced antiinflammatory properties but not to the same extent as HDL from AgNO3-injected mice. SAA-enriched HDL colocalized with cell surface-associated extracellular matrix (ECM) of adipocytes, suggesting impaired access to the plasma membrane. Enzymatic digestion of proteoglycans in the ECM restored the ability of SAA-containing HDL to inhibit palmitate-induced inflammation and cholesterol efflux. Collectively, these findings indicate that inflammation results in a loss of the antiinflammatory properties of HDL on adipocytes, which appears to partially result from the SAA component of HDL binding to cell-surface proteoglycans, thereby preventing access of HDL to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci83475"xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Tang C."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Subramanian S."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Elkon K.B."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Han C.Y."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Shao B."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Wight T.N."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "de Beer F.C."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "de Beer M.C."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "O'Brien K.D."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Marcovina S.M."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Osborne W.R."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Guevara M.E."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Omer M."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Chait A."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Vaisar T."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/author | "Wietecha T."xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/pages | "266-281"xsd:string |
| http://purl.uniprot.org/citations/26642365 | http://purl.uniprot.org/core/title | "Serum amyloid A impairs the antiinflammatory properties of HDL."xsd:string |