| http://purl.uniprot.org/citations/26643293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26643293 | http://www.w3.org/2000/01/rdf-schema#comment | "Canonical Wnt/β-catenin signaling is often aberrantly activated in tumor cells and required for tumor growth. The internalization of Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) induced by Wnt ligands is commonly thought to be critical for Wnt/β-catenin signaling activation. However, in contrast to theses previous studies, we here show that persistent excessive stimulation with a canonical Wnt ligand Wnt3a could induce a long-term decreased expression level of membrane LRP6, which prevented nuclear β-catenin accumulation and tumor cell;proliferation. Importantly, Wnt3a was robustly upregulated following serum deprivation. The upregulated Wnt3a under serum deprivation was responsible for LRP6 internalization, decreased accumulation of nuclear β-catenin, and further inhibition of tumor cell proliferation. It has well been known that insufficient blood supply during tumor development occurs frequently, causing a worsening environment for tumor growth. Therefore, these results reveal a novel inhibitory role of Wnt3a on canonical Wnt/β-catenin signaling and cancer cell proliferation when there is an insufficient blood supply during tumor development, which might be a potential mechanism for tumor evasion within a worsening environment."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2015.11.025"xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Yan H."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "He Q."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/author | "Wo D."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/pages | "32-41"xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/title | "Wnt3a suppresses Wnt/beta-catenin signaling and cancer cell proliferation following serum deprivation."xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://purl.uniprot.org/core/volume | "341"xsd:string |
| http://purl.uniprot.org/citations/26643293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26643293 |
| http://purl.uniprot.org/citations/26643293 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26643293 |
| http://purl.uniprot.org/uniprot/#_P56704-mappedCitation-26643293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26643293 |
| http://purl.uniprot.org/uniprot/P56704 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26643293 |