| http://purl.uniprot.org/citations/26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26647819 | http://www.w3.org/2000/01/rdf-schema#comment | "The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, the degree and duration of HIF-1α expression in hypoxia must be carefully balanced within cells in order to avoid unwanted side effects associated with excessive activity. The expression of HIF-1α mRNA is suppressed in prolonged hypoxia, suggesting that the control of HIF1A gene transcription is tightly regulated by negative feedback mechanisms. Little is known about the resolution of the HIF-1α protein response and the suppression of HIF-1α mRNA in prolonged hypoxia. Here, we demonstrate that the Repressor Element 1-Silencing Transcription factor (REST) binds to the HIF-1α promoter in a hypoxia-dependent manner. Knockdown of REST using RNAi increases the expression of HIF-1α mRNA, protein and transcriptional activity. Furthermore REST knockdown increases glucose consumption and lactate production in a HIF-1α-(but not HIF-2α-) dependent manner. Finally, REST promotes the resolution of HIF-1α protein expression in prolonged hypoxia. In conclusion, we hypothesize that REST represses transcription of HIF-1α in prolonged hypoxia, thus contributing to the resolution of the HIF-1α response."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep17851"xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Taylor C.T."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Cummins E.P."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Cheong A."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Cavadas M.A."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Crifo B."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Manresa M.C."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Mesnieres M."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Scholz C.C."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/author | "Selfridge A.C."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/pages | "17851"xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/title | "REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia."xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26647819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26647819 |
| http://purl.uniprot.org/citations/26647819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26647819 |
| http://purl.uniprot.org/uniprot/#_A0A087X1C2-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PQA1-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |
| http://purl.uniprot.org/uniprot/#_A0PJ83-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |
| http://purl.uniprot.org/uniprot/#_L0B1R1-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |
| http://purl.uniprot.org/uniprot/#_L0B1R5-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |
| http://purl.uniprot.org/uniprot/#_L0B1S6-mappedCitation-26647819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26647819 |