DESCRIBE <http://purl.uniprot.org/citations/26650256>

Subject	Predicate	Object
http://purl.uniprot.org/citations/26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26650256	http://www.w3.org/2000/01/rdf-schema#comment	" Background Transketolase-like protein 1 (TKTL1) is an isoform of tranketolase, a key protein in a cancer cell's glucose metabolism that causes rapid cell growth and controls the non-oxidative part of the pentose phosphate pathway (PPP). Its overexpression occurs in several human cancer types. Our purpose was to study whether TKTL1 expression in colorectal cancer tissue associates with these patients' prognosis. Methods We collected retrospectively patient data and tissue samples from 840 colorectal cancer patients treated at Helsinki University Hospital, then stained tumor tissue microarrays for TKTL1 by immunohistochemistry, and compared immunohistochemical tissue expression with clinico-pathological parameters and survival. Results High expression of TKTL1 associated with high Dukes stage, non-mucinous adenocarcinoma, and left-sided disease. Patients with high TKTL1 expression had poorer prognosis than those with low expression, with a 5-year disease-specific survival of 55.7% vs. 62.7%. Conclusion We show that high TKTL1 in tumor tissue can lead to poor survival in colorectal cancer. TKTL1 thus can serve as a candidate marker for identifying patients at risk of recurrent disease."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.org/dc/terms/identifier	"doi:10.1080/15384047.2015.1121347"xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/author	"Haglund C."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/author	"Hagstrom J."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/author	"Bockelman C."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/author	"Koskensalo S."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/author	"Ahopelto K."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/date	"2016"xsd:gYear
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/name	"Cancer Biol Ther"xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/pages	"163-168"xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/title	"Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer."xsd:string
http://purl.uniprot.org/citations/26650256	http://purl.uniprot.org/core/volume	"17"xsd:string
http://purl.uniprot.org/citations/26650256	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/26650256
http://purl.uniprot.org/citations/26650256	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/26650256
http://purl.uniprot.org/uniprot/#_A2ID95-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_A2ID96-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_B7Z7A6-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_B7Z7I0-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_B7Z7M4-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_A8K859-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/#_P51854-mappedCitation-26650256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/B7Z7A6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/P51854	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26650256
http://purl.uniprot.org/uniprot/B7Z7I0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26650256