| http://purl.uniprot.org/citations/26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26651607 | http://www.w3.org/2000/01/rdf-schema#comment | "Although SOX2(+) stem cells are present in the postnatal pituitary gland, how they are regulated molecularly and whether they are required for pituitary functions remain unresolved questions. Using a conditional knockout animal model, here we demonstrate that ablation of the canonical Notch signaling in the embryonic pituitary gland leads to progressive depletion of the SOX2(+) stem cells and hypoplastic gland. Furthermore, we show that the SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period. However, we found that within several weeks postpartum, the SOX2(+) stem cells switch to an essentially dormant state and are no longer required for homeostasis/tissue adaptation. Our results present a dynamic tissue homeostatic model in which stem cells provide an initial contribution to the growth of the neonatal pituitary gland, whereas the mature gland can be maintained in a stem cell-independent fashion."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2015.11.001"xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/author | "Taylor H."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/author | "Tollkuhn J."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/pages | "1196-1209"xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/title | "Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland."xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26651607 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26651607 |
| http://purl.uniprot.org/citations/26651607 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTV5-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A0M6L0K7-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_D3Z280-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_E0CZF7-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A0F7RQR1-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVE0-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW5-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |
| http://purl.uniprot.org/uniprot/#_A0A338P7A6-mappedCitation-26651607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26651607 |