| http://purl.uniprot.org/citations/26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26653852 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor cells that acquire long-term self-renewal ability and multipotency at the end of organogenesis. The process through which this is achieved often remains unclear. Here, we discovered that long-term hair follicle stem cells arise from embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/β-catenin signaling. Hair follicle initiation is marked by placode formation, which depends on the activation of Wnt/β-catenin signaling. Soon afterwards, a region with attenuated Wnt/β-catenin signaling emerges in the upper follicle. Embryonic progenitor cells residing in this region gain expression of adult stem cell markers and become definitive long-term hair follicle stem cells at the end of organogenesis. Attenuation of Wnt/β-catenin signaling is a prerequisite for hair follicle stem cell specification because it suppresses Sox9, which is required for stem cell formation."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.10567"xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/author | "Jiang K."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/pages | "e10567"xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/title | "Embryonic attenuated Wnt/beta-catenin signaling defines niche location and long-term stem cell fate in hair follicle."xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26653852 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26653852 |
| http://purl.uniprot.org/citations/26653852 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26653852 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_D4Q8H8-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_D4Q8I4-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VMT3-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |
| http://purl.uniprot.org/uniprot/#_A2ABQ7-mappedCitation-26653852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26653852 |