http://purl.uniprot.org/citations/26655552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26655552 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundLow-range troponin elevations without clear coronary manifestations remain a major diagnostic challenge. We sought to determine if troponin velocity could allow for early identification of patients without an obvious cardiac diagnosis and who are at increased risk for cardiac-specific events.Methods & resultsAll patients presenting to South Australian public hospitals between 1 September 2011 and 30 September 2012, with at least two troponin measurements during the first 6h after ED presentation were included. Diagnoses were classified as 'coronary', 'non-coronary cardiac', and 'non-cardiac' using the International Classification of Diseases 10 codes. The relationship between troponin velocity and cardiac-specific mortality and combined cardiac outcome (death and myocardial infarction) was assessed using Fine and Gray competing risk models in patients with an initial troponin <52 ng/L. Sensitivity analyses were performed using different initial and maximum troponin cut-off values. In total, 7300 patients were identified. A troponin velocity of 2.5 ng/L/h or greater in the non-cardiac (n=2793) patient group was significantly associated with an increased risk for 12-month cardiac mortality (sub-hazard ratio [SHR] 2.90, 95% CI 1.33-6.34) and combined cardiac outcome (SHR 2.08, 95% CI 1.01-4.27). This association was consistent for coronary (n=3835) and non-coronary cardiac (n=672) patient groups, and remained after sensitivity analyses.ConclusionsThe significant association observed across all patient groups suggests that troponin velocity could be used for early risk stratification of patients with low-range troponin elevations without clear cardiac symptoms. These results may help guide future clinical trials aimed at assessing the utility of cardiac-targeted interventions in this challenging patient population."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijcard.2015.11.132"xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "French J."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Chuang A."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Hancock D.G."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Cullen L."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Chew D.P."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Horsfall M."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/author | "Alhammad N.J."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/name | "Int J Cardiol"xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/pages | "106-111"xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/title | "The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis."xsd:string |
http://purl.uniprot.org/citations/26655552 | http://purl.uniprot.org/core/volume | "204"xsd:string |
http://purl.uniprot.org/citations/26655552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26655552 |
http://purl.uniprot.org/citations/26655552 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26655552 |
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