| http://purl.uniprot.org/citations/26667768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26667768 | http://www.w3.org/2000/01/rdf-schema#comment | "Several CD4+ T helper (Th) cell subsets are shown to play a role in atherosclerotic lesion formation and progression. We investigated the frequencies of IL-17 and IFN-γ producing CD4+ T-cell subsets in the peripheral blood mononuclear cells (PBMCs) of 10 patients with atherosclerosis and 6 individuals with normal/insignificant coronary artery disease. Th1 and Th17 memory and effector T-cells were enumerated by flowcytometry and correlated with the clinical data and lipid profiles of the subjects. We found the ex-vivo (P=0.0001) and in-vitro production of IL-17 (P=0.001) but not IFN-γ by CD4+ memory T-cells of patients. CD45RO+ memory cells were the major producers of IL-17 and the CD4+CD45RO+PD-1-T-cells of the patients produced higher levels of IFN-γ than controls (P=0.02). Positive correlations between the frequency of CD4+CD45RO+IL-17+IFN-γ-T-cells and serum LDL-C (P=0.007), triglyceride (P=0.02), and systolic (P=0.001) and diastolic (P=0.009) blood pressures (BP) were found. The frequency of CD4+CD45RO+IL-17-IFN-γ-T-cells, which was higher in controls than patients, showed negative correlations with the serum LDL-C (P=0.01) and triglyceride (P=0.02) levels and systolic (P=0.003) and diastolic (P=0.01) BPs. The ex-vivo Th17 deviation of memory T-cells in atherosclerosis and high PD-1 expression are associated with the correlates of atherogenesis such as LDL, TG, and BP."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/author | "Doroudchi M."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/author | "Golmoghaddam H."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/author | "Behnamfar N."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/author | "Zibaeenezhad M.J."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/name | "Cell Mol Biol (Noisy-le-grand)"xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/pages | "17-23"xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/title | "CD45RO+ memory T-cells produce IL-17 in patients with atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/26667768 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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