| http://purl.uniprot.org/citations/26667836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26667836 | http://www.w3.org/2000/01/rdf-schema#comment | "C-type lectin receptors (CLRs) are essential in shaping the immune response to fungal pathogens. Vaccine-induced resistance requires Dectin-2 to promote differentiation of antifungal Th1 and Th17 cells. Since Dectin-2 and MCL heterodimerize and both CLRs use FcRγ as the signaling adaptor, we investigated the role of MCL in vaccine immunity to the fungal pathogen Blastomyces dermatitidis. MCL(-/-) mice showed impaired vaccine resistance against B. dermatitidis infection compared to that of wild-type animals. The lack of resistance correlated with the reduced recruitment of Th17 cells to the lung upon recall following experimental challenge and impaired interleukin-17 (IL-17) production by vaccine antigen-stimulated splenocytes in vitro. Soluble MCL fusion protein recognized and bound a water-soluble ligand from the cell wall of vaccine yeast, but the addition of soluble Dectin-2 fusion protein did not augment ligand recognition by MCL. Taken together, our data indicate that MCL regulates the development of vaccine-induced Th17 cells and protective immunity against lethal experimental infection with B. dermatitidis."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.01263-15"xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/author | "Klein B."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/author | "Wuthrich M."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/author | "Lerksuthirat T."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/pages | "635-642"xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/title | "The C-Type Lectin Receptor MCL Mediates Vaccine-Induced Immunity against Infection with Blastomyces dermatitidis."xsd:string |
| http://purl.uniprot.org/citations/26667836 | http://purl.uniprot.org/core/volume | "84"xsd:string |
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