| http://purl.uniprot.org/citations/26671266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26671266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26671266 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is not fully understood. Here we report that lipoprotein production, autophagy and lysosomal lipolysis are linked to modulate life span in a conserved fashion. We find that overexpression of the yolk lipoprotein VIT/vitellogenin reduces the life span of long-lived animals by impairing the induction of autophagy-related and lysosomal genes necessary for longevity. Accordingly, reducing vitellogenesis increases life span via induction of autophagy and lysosomal lipolysis. Life-span extension due to reduced vitellogenesis or enhanced lysosomal lipolysis requires nuclear hormone receptors (NHRs) NHR-49 and NHR-80, highlighting novel roles for these NHRs in lysosomal lipid signaling. In dietary-restricted worms and mice, expression of VIT and hepatic APOB (apolipoprotein B), respectively, are significantly reduced, suggesting a conserved longevity mechanism. Altogether, our study demonstrates that lipoprotein biogenesis is an important mechanism that modulates aging by impairing autophagy and lysosomal lipolysis."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2015.1127464"xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2015.1127464"xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Hansen M."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Hansen M."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Gonzalez J."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Gonzalez J."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Dillin A."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Dillin A."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Seah N.E."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Seah N.E."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Lapierre L.R."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Lapierre L.R."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Henderson H.R."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Henderson H.R."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Laguer J."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Laguer J."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Petrashen A.P."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "Petrashen A.P."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "de Magalhaes Filho C.D."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/author | "de Magalhaes Filho C.D."xsd:string |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26671266 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |