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| http://purl.uniprot.org/citations/26673323 | http://www.w3.org/2000/01/rdf-schema#comment | "KDM5 family proteins are critically important transcriptional regulators whose physiological functions in the context of a whole animal remain largely unknown. Using genome-wide gene expression and binding analyses in Drosophila adults, we demonstrate that KDM5 (Lid) is a direct regulator of genes required for mitochondrial structure and function. Significantly, this occurs independently of KDM5's well-described JmjC domain-encoded histone demethylase activity. Instead, it requires the PHD motif of KDM5 that binds to histone H3 that is di- or trimethylated on lysine 4 (H3K4me2/3). Genome-wide, KDM5 binding overlaps with the active chromatin mark H3K4me3, and a fly strain specifically lacking H3K4me2/3 binding shows defective KDM5 promoter recruitment and gene activation. KDM5 therefore plays a central role in regulating mitochondrial function by utilizing its ability to recognize specific chromatin contexts. Importantly, KDM5-mediated regulation of mitochondrial activity is likely to be key in human diseases caused by dysfunction of this family of proteins."xsd:string |
| http://purl.uniprot.org/citations/26673323 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.11.007"xsd:string |
| http://purl.uniprot.org/citations/26673323 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26673323 | http://purl.uniprot.org/core/author | "Secombe J."xsd:string |
| http://purl.uniprot.org/citations/26673323 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26673323 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
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| http://purl.uniprot.org/citations/26673323 | http://purl.uniprot.org/core/title | "The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif."xsd:string |
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