| http://purl.uniprot.org/citations/26680205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26680205 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8(+) T cells and NK cells protect from viral infections by killing virally infected cells and secreting interferon-γ. Several inhibitory receptors limit the magnitude and duration of these anti-viral responses. NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on NK cells and activated CD8(+) T cells. Previous studies on the impact of CD94/NKG2A heterodimers on anti-viral responses have yielded contrasting results and the in vivo function of NKG2A remains unclear. Here, we generated Klrc1(-/-) mice and found that NKG2A is selectively required for resistance to ectromelia virus (ECTV). NKG2A functions intrinsically within ECTV-specific CD8(+) T cells to limit excessive activation, prevent apoptosis, and preserve the specific CD8(+) T cell response. Thus, although inhibitory receptors often cause T cell exhaustion and viral spreading during chronic viral infections, NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2015.11.005"xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Buller R.M."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Schriewer J."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Yokoyama W.M."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Gilfillan S."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Pircher H."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Hembrador E."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Le Friec G."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Plougastel B.F."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Rapaport A.S."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/author | "Crump R."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/pages | "1112-1124"xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/title | "The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection."xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/26680205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26680205 |
| http://purl.uniprot.org/citations/26680205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26680205 |
| http://purl.uniprot.org/uniprot/#_E9QAJ6-mappedCitation-26680205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680205 |