| http://purl.uniprot.org/citations/26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26680304 | http://www.w3.org/2000/01/rdf-schema#comment | "Commissural axon guidance depends on a myriad of cues expressed by intermediate targets. Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossing commissural axons to mediate floor plate repulsion in the mouse spinal cord. Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissural axons prior to midline crossing and can mediate precrossing semaphorin-induced repulsion in vitro. How premature semaphorin-induced repulsion of precrossing axons is suppressed in vivo is not known. We discovered that a novel source of floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfinding. Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precrossing axons in the ventral spinal cord, which can be rescued by inhibiting plexin-A1 signaling in vivo. Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning as a molecular sink to sequester semaphorins, preventing premature repulsion of precrossing axons prior to subsequent down-regulation, and allowing for semaphorin-mediated repulsion of post-crossing axons."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.268086.115"xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Yoshida Y."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Martinez E."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Tessier-Lavigne M."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Olsen O."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Maness P.F."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Kaprielian Z."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Tran T.S."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/author | "Hernandez-Enriquez B."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/pages | "2617-2632"xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/title | "Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing."xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/26680304 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26680304 |
| http://purl.uniprot.org/citations/26680304 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26680304 |
| http://purl.uniprot.org/uniprot/#_A0A087WPS6-mappedCitation-26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680304 |
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| http://purl.uniprot.org/uniprot/#_A0A087WPI9-mappedCitation-26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680304 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUU1-mappedCitation-26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680304 |
| http://purl.uniprot.org/uniprot/#_A0A087WST5-mappedCitation-26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680304 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW74-mappedCitation-26680304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26680304 |