| http://purl.uniprot.org/citations/26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26683305 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterocyclic aromatic amines formed in cooked meat may be an underlying mechanism for the red meat-colorectal cancer (CRC) association. These compounds require bioactivaction by N-acetyltransferase 2 (NAT2). An interaction effect between red meat consumption and NAT2 in increasing CRC risk has been inconsistently reported in whites. We investigated this interaction in two populations in which the high-activity rapid NAT2 phenotype is 10- and 2-fold more common than in whites. We meta-analyzed four studies of Japanese (2,217 cases, 3,788 controls) and three studies of African Americans (527 cases, 4,527 controls). NAT2 phenotype was inferred from an optimized seven-SNP genotyping panel. Processed and total red meat intakes were associated with an increased CRC risk in Japanese and in both ethnic groups combined (P's ≤ 0.002). We observed an interaction between processed meat intake and NAT2 in Japanese (P = 0.04), African Americans (P = 0.02), and in both groups combined (P = 0.006). The association of processed meat with CRC was strongest among individuals with the rapid NAT2 phenotype (combined analysis, OR for highest vs. lowest quartile: 1.62, 95% CI: 1.28-2.05; Ptrend = 8.0×10-5), intermediate among those with the intermediate NAT2 phenotype (1.29, 95% CI: 1.05-1.59; Ptrend = 0.05) and null among those with the slow phenotype (Ptrend = 0.45). A similar interaction was found for NAT2 and total red meat (Pinteraction = 0.03). Our findings support a role for NAT2 in modifying the association between red meat consumption and CRC in Japanese and African Americans."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0144955"xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Iwasaki M."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Berndt S.I."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Tsugane S."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Kono S."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Keku T.O."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Le Marchand L."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Wilkens L.R."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/author | "Haiman C.A."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/pages | "e0144955"xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/title | "Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans."xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26683305 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26683305 |
| http://purl.uniprot.org/citations/26683305 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26683305 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5S1-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5X5-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A4Q6-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5J2-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |
| http://purl.uniprot.org/uniprot/#_A4Z6U4-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |
| http://purl.uniprot.org/uniprot/#_A4Z6U6-mappedCitation-26683305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26683305 |