| http://purl.uniprot.org/citations/26687224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26687224 | http://www.w3.org/2000/01/rdf-schema#comment | "The cleft is an integral part of synapses, yet its macromolecular organization remains unclear. We show here that the cleft of excitatory synapses exhibits a distinct density profile as measured by cryoelectron tomography (cryo-ET). Aiming for molecular insights, we analyzed the synapse-organizing proteins Synaptic Cell Adhesion Molecule 1 (SynCAM 1) and EphB2. Cryo-ET of SynCAM 1 knockout and overexpressor synapses showed that this immunoglobulin protein shapes the cleft's edge. SynCAM 1 delineates the postsynaptic perimeter as determined by immunoelectron microscopy and super-resolution imaging. In contrast, the EphB2 receptor tyrosine kinase is enriched deeper within the postsynaptic area. Unexpectedly, SynCAM 1 can form ensembles proximal to postsynaptic densities, and synapses containing these ensembles were larger. Postsynaptic SynCAM 1 surface puncta were not static but became enlarged after a long-term depression paradigm. These results support that the synaptic cleft is organized on a nanoscale into sub-compartments marked by distinct trans-synaptic complexes."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2015.11.011"xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Kong G.K."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Tang A.H."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Bewersdorf J."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Biederer T."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Stein V."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Blanpied T.A."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Lucic V."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Krupp A.J."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Perez de Arce K."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Allgeyer E."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Metzbower S.W.R."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/author | "Schrod N."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/pages | "1165-1172"xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/title | "Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains."xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/26687224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26687224 |
| http://purl.uniprot.org/citations/26687224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26687224 |
| http://purl.uniprot.org/uniprot/Q8R5M8#attribution-F875EBC39EC0A5FF3FC7CF1EB3BF9DED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26687224 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS08-mappedCitation-26687224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26687224 |