| http://purl.uniprot.org/citations/26687600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26687600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26687600 | http://www.w3.org/2000/01/rdf-schema#comment | "Multicellular organisms have multiple homologs of the yeast ATG8 gene, but the differential roles of these homologs in autophagy during development remain largely unknown. Here we investigated structure/function relationships in the two C. elegans Atg8 homologs, LGG-1 and LGG-2. lgg-1 is essential for degradation of protein aggregates, while lgg-2 has cargo-specific and developmental-stage-specific roles in aggregate degradation. Crystallography revealed that the N-terminal tails of LGG-1 and LGG-2 adopt the closed and open form, respectively. LGG-1 and LGG-2 interact differentially with autophagy substrates and Atg proteins, many of which carry a LIR motif. LGG-1 and LGG-2 have structurally distinct substrate binding pockets that prefer different residues in the interacting LIR motif, thus influencing binding specificity. Lipidated LGG-1 and LGG-2 possess distinct membrane tethering and fusion activities, which may result from the N-terminal differences. Our study reveals the differential function of two ATG8 homologs in autophagy during C. elegans development."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.11.019"xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.11.019"xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wu F."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wu F."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Noda N.N."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Noda N.N."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Fang T.C."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Fang T.C."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Fujioka Y."xsd:string |
| http://purl.uniprot.org/citations/26687600 | http://purl.uniprot.org/core/author | "Fujioka Y."xsd:string |