| http://purl.uniprot.org/citations/26691751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26691751 | http://www.w3.org/2000/01/rdf-schema#comment | "Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2015.148"xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/author | "Becker B."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/author | "Antebi A."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/author | "Greer E.L."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/author | "Latza C."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/pages | "229-238"xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/title | "Mutation of C. elegans demethylase spr-5 extends transgenerational longevity."xsd:string |
| http://purl.uniprot.org/citations/26691751 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q09956-mappedCitation-26691751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26691751 |
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