| http://purl.uniprot.org/citations/26694763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26694763 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis is a vital biological mechanism representing the adaptive response to a variety of pathological stimuli such as hypoxia. It is regulated by several pro-angiogenic and anti-angiogenic microRNAs. Studies have demonstrated an altered microRNA-185 (miR-185) expression in endothelial cells under hypoxic conditions; however, its role in angiogenesis has not been elucidated. We investigated the role of miR-185 in angiogenesis and found that miR-185 had an inhibitory effect on cell proliferation, migration, and tube formation. Stromal interaction molecule 1 (STIM1) appeared to be a direct target of miR-185 by computational prediction; this was confirmed by luciferase reporter assay. Silencing of the STIM1 gene was found to mimic miR-185-mediated inhibition of angiogenesis. STIM1 overexpression eliminated the anti-angiogenic effect of miR-185. Our study results suggest a direct interaction between miR-185 and STIM1 mRNA in microvascular endothelial cells. MicroRNA-185 acted as a negative regulator of angiogenesis in microvascular endothelial cells through downregulation of the STIM1 protein."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10572"xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Cui L."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Hou J."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/author | "Tian B."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/pages | "318-328"xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/title | "MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1."xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/26694763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26694763 |
| http://purl.uniprot.org/citations/26694763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26694763 |
| http://purl.uniprot.org/uniprot/Q13586#attribution-D4BEED421104DCA489F65A66930C1DAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26694763 |